Metacam, Rimadyl and Previcox – Are These Drugs Safe to Use for Arthritis in Dogs?

Drug treatments for osteoarthritis have one of two primary objectives: Firstly, to make the patient more comfortable i.e. reduce the symptoms and signs of the condition. Secondly, and this is one of the major goals of osteoarthritis research, to slow or even reverse the osteoarthritis process that is causing progressive deterioration and loss of articular cartilage. Compounds that can slow the osteoarthritis process down are referred to as Disease (or structure) Modifying Drugs (DMOADs).

In clinical practice for both humans and dogs, the concept of disease modification is still rather theoretical with no treatment proven to have this effect. The main second line treatments in small animal veterinary practice are anti-inflammatory drugs.

Anti-inflammatory drugs

Most canine patients with some lameness associated with osteoarthritis will be best treated with anti-inflammatory drugs.When we talk about anti-inflammatories and OSTEOarthritis we are virtually always referring to the Nonsteroidal anti-inflammatories or the NSAIDs (pronounced as ‘en-sayds’).

The NSAIDs are a group of quite different drugs but they all work in a similar way. They all act to block the production of prostaglandins in body tissues. Prostaglandins are a family of chemicals produced by the body that promote inflammation, pain, and fever. As well as making the local blood capillaries more leaky (causing local swelling) they will make nerve fibres more sensitive and hence make us feel pain.

Anti-inflammatory drugs act to reduce prostaglandin production in the tissues and hence reduce inflammation and discomfort. Prostaglandins also have some beneficial and important protective effects in the body. These include regulating blood flow to the kidneys and maintaining a protective mucus barrier in the lining of the stomach. It is in blocking these actions as well as the ‘bad’ effects of prostaglandins that NSAIDs can cause some nasty and potentially fatal side effects.

NSAIDs act by blocking the action of an enzyme called cyclooxygenase (COX), which is vital to the production of prostaglandins in the tissues. There are at least two forms of this enzyme referred to as COX-1 and COX-2.  Nonsteroidal anti-inflammatory drugs (NSAIDs) block the COX enzymes and reduce prostaglandins throughout the body. As a consequence, ongoing inflammation, pain, and fever are reduced.

Since the prostaglandins protect the stomach and maintain a healthy blood flow to the kidneys, NSAIDs can cause stomach inflammation, gastrointestinal ulcers and cause kidney damage by reducing renal blood flow. The risk of serious kidney damage is magnified in dehydrated patients or patients in circulatory shock from blood loss.  COX-1 is particularly important in housekeeping functions and COX-2 is increased in the presence of inflammation. NSAIDs that preferentially block COX-2 seem to cause fewer gastrointestinal side effects.

COX-2 selective NSAIDs have become available for use in the dog. Three of the newer and most widely used agents, Metacam, Rimadyl and Previcox are licensed for use in a number of countries. They show preferential inhibition of COX-2 and show a lower incidence of side effects compared to drugs such as aspirin.

Generally anti-inflammatories alone seem to work well in the dog with arthritis. There are some drawbacks, mainly vomiting and diarrhoea, which can limit their usefulness in some patients and, lead to very serious complications in some. Their effects on reducing blood flow to the kidneys can be devastating in certain situations, typically those where there is some form of circulatory system problem such as shock or dehydration.

Play it Safe

Although NSAIDs have been associated with some serious side effects and adverse reactions, they provide safe, effective pain relief in the vast majority of patients. However, they are potentially very dangerous drugs and should be respected. I would advise the following rules are adhered to in order to minimize the chances of adverse reactions:

1.    Only use a veterinary licensed product provided/recommended by your veterinarian. Some human preparations have a much narrower safety profile in dogs than in people. Don’t do it!

2.    Stop using any NSAID immediately if your dog develops inappetance, vomiting and or diarrhoea. Consult your veterinary professional straightaway.

3.    Always consult your veterinarian before administering any other medications alongside NSAIDs.

4.    If at a veterinary visit you see a different person at the clinic, always remind them that your dog is on NSAIDs – It should be on your pet’s clinical notes but better to play it safe and mention it.

The NSAIDs are an important component of your pet’s arthritis treatment plan but they should be used with care and under the strict guidance of your vet. They are just one factor in successfully managing canine osteoarthritis.

Why Should You Choose Online Veterinary Distributors?

Most of us love and take care of pets as if they are our family members. You must be taking your pet to a veterinarian every time it is not doing well but do you ever think about the stores where the veterinarians get the medicines for your pet? You should be aware about such facts as it concerns the health of your pet.

So, if you are curious to know about the dealers who provide the best quality medicines to a vet, you should look up the online veterinary distributors. A major advantage that vets get for buying from these dealers is that while they can get the medicines that are not available in the markets anymore, they can also buy the medicines that have been introduced into the markets recently. While the vets are supplied with the generic compositions of medicines, they also get compounded drugs from these distributors.

One of the major advantages of buying from online veterinary distributors is that the medicines are shipped to the vets in required quantities. A substantial stock of medicinal supplies ensure the owners of the pets that there is a round the clock availability of medicines whenever they visit a veterinary clinic. There are also many other benefits that the online veterinary medicine stores have over the brick and mortar clinics such as:

Convenience

Vets have the convenience of ordering medicines from the comforts of their home or clinic. It is also convenient for the pet owners to get medicines that are manufactured in another city or country. The vets can order mixtures and compounds that are made according to your pet’s health condition.

Low prices

Online veterinary distributors do not have to spend in overhead costs as in the case of brick and mortar stores. Therefore, they can make considerable savings in the market price of medicines, which spells huge discounts for you.

Wider range

A reputed online vet store generally has a wide range of medicines. A major benefit of buying from online vet stores is that you can buy a substantial stock to last you really long. A veterinarian not only gets a variety of generic and compounded drugs but can buy drugs in bulk amounts too. Thus, a Veterinarian must look for client-centric veterinary online distributors like Amatheon.com. While a distributor like Amatheon takes care of their specific requirement of medicines, it also provides automatic renewals. Ready to place your order?

Horse and Vet Supplements Are Helping Bodybuilders Just As Much As Vet Drugs

Most of us have had experiences with veterinary drugs… simply incredible drugs that generally are targeted towards horses or dogs… and the ensuing results have probably always been spectacular. However, when you first start, the concept of ingesting something intended for our four legged friends can be a bit jarring. You wonder if you’re going to take Winstrol and end up jumping 5 foot fences, or if you’re going to get on all fours, pee on your neighbor’s mailbox and chase a rabbit if you sample some of Fido’s hormonal medication – and haven’t we all had a moment on all fours where it’s been embarrassing? Scratch that.

Look, there’s definitely a reason that veterinarian drugs are desired by many and why taking the lead of race and show horse performance may be the best plan. Sport horses are insanely amazing athletes. Not just your typical race horses, but dressage horses, jumping horses, cross country and steeplechase horses, and so many others there are too many to mention. Basically, these capable athletes are not only as aesthetically pleasing and as muscle solid as you are as a bodybuilder, they tend to be really geared up for performance. They perform like well-oiled machines. Much of that is genetic predisposition and they have evolved over the years to become such powerful animals. But, a lot has been cultivated beyond the regular level of performance and conditioning by way of animal performance and growth drugs and equine specifically equine sports supplements.

Oh yes, these hooved homies are supplement junkies much like you! Alright, they aren’t, but their owners certainly are. As a matter of fact, the equestrian world is downright fanatical when it comes to “getting the edge”. It’s really quite astounding that trends in the equestrian world so closely resemble the main threads of bodybuilding supplementation. We tend to take creatine, horses take creatine. We take Gamma-Oryzanol, horses take G-O. Horses take Glucosamine and Chondroitin, and we take it, in addition to Hyaluronic acid (horses took it first) and the list just keeps going on and on.

The idea is, horses and people aren’t so different in regards to athletic needs. While bodybuilding may be considered an aesthetic-only pursuit, those of us who train all know that in the gym, it’s all about obtaining higher levels of performance! The most exciting thing is, there is a supplement that is based on horse performance principles that is like the supplement version of we have all enjoyed out of veterinary Anabolics over the years. It really is the equivalent in regards to supplementation – something that has up until now been very difficult to obtain in the bodybuilding world.

I used to think that having a supplement that was as good as Winstrol and Equipoise are as an AAS, would be an impossible dream. Based on pre-workout (energy), workout (anti-fatigue/ lactic acid blocking properties) and post-workout (recovery), it’s like vet Anabolics – you tend to get the most clear results for the fewest hassles. It’s a real “bang for the buck” supplement in the same way Winstrol-V and Equipoise is a damn good steroid cycle! And believe you me, the pre-performance and recovery aspects of the equestrian supplement world are vastly more advanced than the human side.

The human version of this equestrian supplement is called TridenosenH, I believe it’s still a littler hard to find, but maybe do some searching on the Internet to see what you come up with. Believe me, this marriage of the equestrian supplement world with the human one is an advancement that’s been long awaited, especially by me.